DIMETHYLAMINOETHANOL (DMAE) | Site about fashion, style and beauty

Mechanism

DMAE (also known as deanol) is a precursor to acetylcholine, a neurotransmitter involved in increased muscle tone. There thus could be firming of the skin via effects on the facial

Table 1 Lack of Effect of Pal-KTTKS on Skin Barrier Properties as Assessed by Transepidermal Water Loss

Time point	Transepidermal water loss (g water/m2/hr)	p value
Placebo formulation	Pal-KTTKS formulation
Baseline	11.15	11.40	p>0.38
4 weeks	8.10	8.24	p>0.60
8 weeks	8.56	8.41	p> 0.60
12 weeks	7.89	8.15	p>0.35

musculature. In addition, acetylcholine may affect the keratinocytes (specifically their proliferation, adhesion, and motility) leading to “epidermal contractility,” leading to a firming/tightening effect on the skin (60). DMAE also has antioxidant properties, which may contribute to its anti-aging effects (61,62).