1. Science and clinical studies: Amino peptides are chemically linked to Palmitic Acid to enhance solubility allowing the peptide to become non-polar to cross lipids bilayers. Palmitoyl Pentapeptide-3, tested in a six-month clinical study, demonstrated improvement in the visual appearance of wrinkles by possibly stimulating fibroblast to rebuild the extra-cellular matrix and induce collagen synthesis. Palmitoyl Tetrapeptide-3 is said to control the secretion of cytokine (IL-6), delaying the effects of premature aging. Recent studies have shown that Palmitoyl Tetrapeptide-3 can make a substantial difference in the appearance of stretch marks. In one study, 93% of subjects showed a marked improvement in the length and depth of stretch marks and wrinkles. In addition, there was a substantial improvement in the skin smoothness and tone. Similarly, Acetyl Hexapeptide-3 is thought to reduce wrinkles by disrupting the nerve signals sent
to tense muscle beneath the dermis—functionally relaxing them and smoothing the overlying skin.
2. Key benefits: Collagen and glycosaminoglycan stimulation, inhibition of cytokines, disruption of nerve signaling.
3. Primary adverse effects: None known.
4. Practical applications in dermatology: May be useful in treating photodamaged skin.