Wrinkles: Cosmetics, Drugs, and Energy-Based Systems

John E. Oblong

The Procter and Gamble Company, Cincinnati, OH, USA

15.1 Introduction 301

15.2 Cosmetics 302

15.2.1 Retinoids 302

15.2.2 Niacinamide 305

15.2.3 Ascorbic Acid 306

15.2.4 Peptides 306

15.2.5 Kinetin (N6-Furfuryladenine) 307

15.3 Beyond Cosmetics—Prescription Technologies 308

15.4 Dermal Fillers and BOTOX Cosmetic 308

15.5 Nonablative Instruments and Techniques 310

15.6 Phototherapy 310

15.6.1 Laser and Intense Pulsed Light 310

15.6.2 Light Emitting Diodes 311

15.6.3 Radiofrequency 312

15.6.4 Fractional Photothermolysis 312

15.7 Discussion 313

References 313

15.1 Introduction

Gurpreet S. Ahluwalia (ed.), Cosmetic Applications of Laser and Light-Based Systems, 301-316,

© 2009 William Andrew Inc.

expansion of the antiaging aesthetic market. On the cosmetic side of this multi-billion dol­lar market, there are currently available to the consumer a literal plethora of products claim­ing to provide various skin-benefit attributes. While historically the market has been driven primarily by moisturizers, there have been significant technical breakthroughs and altera­tions in social perceptions that have fueled the robust expansion and growth, both in the cosmetic as well in the professional market (cosmetic surgeons, dermatologists, plastic surgeons). The numerous technological advances have allowed the professional to be able to provide to patients significant transformations with reduced negative side effects and at lower costs. Due to limitations, this chapter will review a few of the options available, with a focus upon technologies that can significantly impact rhytides (fine lines and wrinkles).