Dapsone is a topical disinfectant gel available by prescription in 5% strength. The brand name for the anti-acne drug is Aczone, and it is made by Allergan (of Botox fame). Dap – sone is a drug that comes from the sulfone family of drugs. Its relation to sulfur explains its antibacterial action.
Double-blind, large-scale studies examining dapsone’s effectiveness on adolescent acne have shown that it is well-tolerated and brought about “clinically meaningful” improvements in acne lesion count after 12 weeks, with improvements continuing with ongoing usage. Side effects were similar to that of the “vehicle gel,” which was not identified in the studies.
Although Aczone is an option for inflammatory acne and research on its efficacy is positive, what’s lacking are critical comparative studies with other known, established anti-acne drugs (both prescription and over-the-counter). I wouldn’t consider Aczone unless you have tried benzoyl peroxide, retinoids, and salicylic acid, all of which have a large body of research proving their efficacy and safety. If those actives haven’t produced satisfactory results, talk to your physician about Aczone/dapsone.
Sources: Cutis, February 2008, pages 171-178 and November 2007, pages 400-410; Journal of Drugs in Dermatology, October 2007, pages 981-987; and Journal of the American Academy of Dermatology, March 2007, pages e1-e10).