1. Science and clinical studies: Two studies have been published whereby vitamin K has been used to minimize purpura production after pulse dye laser treatments
(17) . Both studies employed approximately 20 subjects, with one evaluating the effects of the ingredient alone and the other with the use of retinol BID weeks before and two weeks after laser treatment. The side of the face treated with topical vitamin K with or without retinol demonstrated significantly lower scores of bruising severity when compared with the side treated with placebo
(18) .
2. Key benefits: Reduces bruising and can minimize damage associated with pulse dye lasers.
3. Primary adverse effects: None noted.
4. Practical applications in dermatology: Using vitamin K, two weeks before and after pulse dye laser treatments may reduce adverse cutaneous reactions. Efficacy for bruising from other etiologies is unknown.