Hemorrhoids, venous conditions including insufficiency, and blunt injuries are approved indications for this herb. It has antiphlogistic, anti-exudative, and anti-edematous effects while it improves venous reflux, lymphatic kinetics, and wound healing. The active compounds include free coumarins including melilotol, hydroxycoumarins such as umbelliferone, flavonoids including kaempferol glycosides, triterpene saponins such as melilotigenin, and volatile oils (3).
Oral administration may lead to hepatoxicity. No cutaneous sensitization or irritation has been reported, but red clover (Trifolium pratense) is a mutagen (13). Sweet clover is administered as a comminuted herb for galenic formulation for infusion, poultice, ointment, suppository, and herbal sachet (3).