Substantiation of Efficacy

Topical SeMet was shown to be effective in protecting against acute and chronic UV damage to the skin. Concentrations as low as 0.02% increased the MED in humans (106) and decreased acute erythema and blistering as well as later UV-induced tanning and skin cancer in Skh:2 mice (105).

Substantiation of Efficacy

Figure 6 Correction of periorbital wrinkles after four months of once-daily treatment with 0.05% L-selenomethioinine lotion.

Furthermore, topical SeMet is highly effective not only in preventing but also in reversing the appearance of photoaging. As shown clinically in Figure 6, periorbital rhytides are decreased significantly in a 56-year-old woman after four months of once – daily application of SeMet (0.05%) cream.

This enhancement of repair of chronic photoaging at the cellular and molecular level was confirmed by histologic and electron microsopic analysis in mice (107). UV-induced hyperkeratosis and epithelial hyperplasia markedly decreased; irregular, damaged collagen was replaced with newly synthesized, fine fibrillar homogeneous collagen; solar elastosis was repaired; and UV-induced infammation resolved—all as (or more) effectively as comparable treatment with topical tretinoin (107). Electron microscopy confirmed repair of dermal collagen and basement membrane anchoring fibrils.

Updated: July 25, 2015 — 12:41 pm