The activation of protease-activated receptor-2 (PAR-2), a seven trans-membrane G-protein coupled receptor, which is expressed in keratinocytes and not in melanocytes, was found to activate keratinocyte phagocytosis, enhancing the melanosome transfer (48). Inhibition of PAR-2 cleavage by serine protease inhibitor, such as RWJ-50353, completely avoids the UVB-induced pigmentation of epidermal analogs (49,50).
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