Cyproterone acetate is a hydroxy-progesterone that blocks the binding of androgens to their receptors. It also inhibits the synthesis of androgens in the adrenal glands and in the skin. Cyproterone acetate is not available in the United States but is available in Canada and Europe. It is incorporated in an oral contraceptive pill at 2 mg per day with ethinyl estradiol. Women with abnormal androgen metabolism can take additional 10-50 mg once daily during the first 10 days of their menstrual cycle (81).
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