1. Science and clinical studies: Co-Q10 plays a vital role in mitochondrial enzymes of the oxidative phosphorylation pathway and is essential for the production of the high-energy phosphate, adenosine triphosphate (ATP), upon which all cellular functions depend. Numerous in vitro studies have been reported demonstrating the antioxidant efficacy of Co-Q10. However, limited clinical studies are available reporting on the benefits of topical administration. One study was found which noted that Co-Q10 penetrates into the viable layers of the epidermis and reduces the level of oxidation measured by weak photon emission and a reduction in wrinkle depth was also shown (33). Co-Q10 also protected against UVA-mediated oxidative stress in human keratinocytes in terms of thiol depletion, activation of specific phosphotyrosine kinases, and prevention of oxidative DNA damage.
2. Key benefits: Antioxidant functions which mediate UVA oxidative stress in human keratinocytes minimizing DNA damage.
3. Primary adverse effects: None known.
4. Practical applications in dermatology: May be useful in treating photodamaged skin.