The application of PDT as a modality for nonablative photorejuvenation is an extension of its efficacy in treating actinic damage and photoaging (for review, see Alexiades – Armenakas) [39]. The application of topical ALA for short incubation times, combined with newer laser and light sources has been shown to be safe and effective for the treatment of actinic keratoses (AK), actinic cheilitis (AC), photodamage, and for photorejuvenation with minimal side effects. Topical ALA has been combined with blue light, LP PDL or IPL. The use of methyl-ALA (MAL) and red light has been developed for AK and potential BCC treatment, though it has not yet been investigated for photorejuvenation.
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