The primary means for photomodulated upregulation of cell activity for collagen synthe­sis by LED is the activation of energy switching mechanisms in mitochrondria, the energy source for cellular activity. Cytochrome molecules are believed to be responsible for the light absorption in mitochrondria. Cytochromes are synthesized from protoporphyrin IX and absorb wavelengths of light from 562 […]

The LED red light (630 nm) has been used for several years in combination with a sen­sitizer (levulinic acid) for photodynamic therapy (PDT) [28]. When exposed to light with the proper wavelength, the sensitizer produces an activated oxygen species, singlet oxygen, that oxidizes the plasma membrane of targeted cells. Due to a lower metabolic rate, […]

Over the course of our multiyear experience with photomodulation, we have observed the reduction of erythema from a variety of causes. Reduction of erythema may be induced from wide-ranging skin injuries, including but not limited to thermal laser treatments, UV burns, radiation therapy, and blunt trauma. In addition, anectodal experience with a series Figure 12.2 […]

12.1.2 Photorejuvenation LED photomodulation can be used both alone, and in combination with a variety of com­mon nonablative rejuvenation procedures in an office setting. Several antiinflammatory and wound-healing applications have surfaced as well, and these are discussed in the subsequent sections. Treatments are delivered using the Gentlewaves® yellow/IR light LED photomodu­lation unit (LightBioScience, Virginia Beach, […]

Robert A. Weiss1, Roy G. Geronemus2, and David H. McDaniel3 Maryland Laser Skin & Vein Institute, Hunt Valley, MD, USA 2New York University Medical Center, New York, NY, USA 3Eastern Virginia Medical School, Virginia Beach, VA, USA 12.1 Introduction 271 12.1.1 Photomodulation 271 12.2 Clinical Applications 272 12.2.1 Photorejuvenation 272 12.3 Antiinflammatory Effects 274 12.4 […]

See Table 11.1 for a list of devices and their corresponding characteristics. 11.2 Treatment Complications and Management The most common side effects, such as erythema, edema, pruritis, flakiness, petechiae/ purpura, and acneiform eruptions are transient and self-limiting. Oral or topical steroids may be given for persistent erythema, edema, and pruritis. However, these symptoms can generally […]

Immediately after treatment, erythema and edema are common, and may persist for two to three days, or slightly longer with ablative treatments, and when more aggressive set­tings are used. Edema is typically most prominent in the periorbital area and usually lasts less than 1 week in most patients [18]. With ablative fractional resurfacing, punctate bleed­ing […]

Prior to treatment, patients should meet with their clinician to discuss their medical his­tory. For patients with a history of cold sores (oral herpes simplex), valacyclovir or acyclo­vir should be prescribed starting on or before the day of treatment. Medications, such as Accutane® should also be stopped 6-12 months prior to treatment, and topical retinoids […]

Fractional photothermolysis may also be beneficial in the treatment of poikiloderma of Civatte. Poikiloderma is a condition characterized by atrophy, hyper – and hypopigmenta – tion, and dilation of blood vessels (telangiectasia) on the neck and chest [26,35,36]. It is most commonly seen in middle-aged and fair-skinned women with a history of sun expo­sure. Early […]