Laser and light treatments for acne have included the FDA-approved blue light and diode 1450 nm laser, both of which act by targeting the sebaceous glands [3]. The disadvantages of these treatments are that they require multiple treatments and are modestly effective, with recurrences being relatively common [3]. The recent strict regulation of isotretinoin, a highly effective acne medication, associated with many untoward effects has reinvigorated the search for acne treatment alternatives, such as PDT. In the 1990s, early studies of red light and lasers following the application of topical ALA for the treatment of acne showed promising efficacy, but with the disadvantage of significant side effects, such as blistering and dyspigmentation [3]. Recently, studies employing topical ALA followed by illumination with either LP, PDL, or IPL have indicated a promising level of safety and efficacy, with little-to-no side effects [4-6]. PDT has become a viable treatment option for acne patients for whom conventional therapies do not work.
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