The search for an effective form of AHA or an extra ingredient that can enhance performance and reduce irritation has been a popular topic of discussion among cosmetics formulators. Gluconolactone is a type of polyhydroxy acid that NeoStrata (the company that developed and patented this ingredient) believes serves both ends: It is supposed to be just as effective as AHAs but also less irritating.
Gluconolactone (PHA) is similar to AHAs. The significant difference between the two is that gluconolactone has a larger molecular structure, which limits its penetration into the skin, resulting in a reduction of irritating side effects in some skin types. Is gluconolactone better for your skin than AHAs? Research indicates that AHA and PHA perform identically, with AHA having a slight edge for improving the appearance of skin and PHA having less risk of irritation (Source: Cutis, February 2003, pages S14-S17).