Treatment of acne is a challenging process due to its multifarious pathogenesis. For this reason, more studies are needed to explore other possible treatments. For example, additional studies are needed to find more effective ways of enhancing the delivery of ALA to its target, possibly through microdermabration, peeling, or using the ester form of ALA (methyl ALA). The use of antibiotics for P acnesand whether or not we should stop using antibiotics before blue light exposure needs to be explored more thoroughly. In addition, studies for the treatment of periodic acne in women (acne related with menstruation) and ALA with intense Laser (PDL) or Light (Intense blue light or other intense pulsed light systems) are other possible areas that can be investigated.