A polyphenol widely distributed in plants, is capable of preventing pigmentation caused by sunburn (34). Ellagic acid inhibits tyrosinase non-competitively in a dose-dependent manner, through its capacity to chelate copper, even if other mechanisms, such as a scavenger effect have been suggested. Interestingly, in brownish guinea pigs (34), ellagic acid induced a reversible inhibition of melanin synthesis only in UV-activated melanocytes (34).
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