1. Science and clinical studies: Topical application of Pantothenic Acid has been shown to provide moisturizer-like benefits, improving stratum corneum hydration, reducing transepidermal water loss, and maintaining skin softness and elasticity. Activation of fibroblast proliferation, which is of relevance in wound healing, has been observed both in vitro and in vivo, and accelerated re – epithelization in wound healing has been demonstrated via transepidermal water loss. Pantothenic Acid has also been shown to have an anti-inflammatory effect reducing UV-induced erythema. In double-blind, placebo-controlled clinical trials, a Pantothenic Acid-containing cream resulted in significantly less damage to the stratum corneum barrier, compared with no pretreatment over three to four weeks.
2. Key benefits: Moisturizer-like benefits, reduction in TEWL, fibroblast activation, and anti-inflammatory potential.
3. Primary adverse effects: Topical administration of Pantothenic Acid preparations are generally well tolerated, with minimal risk of skin irritancy or sensitization.
4. Practical applications in dermatology: Pantothenic Acid may be beneficial in patients who have undergone skin transplantation or scar treatment, or therapy for burn injuries and different dermatoses.