1. Science and clinical studies: Niacinamide was evaluated clinically in Japanese women for the inhibition of pigmentation. Eighteen subjects with hyperpigmentation received either a 5% Niacinamide containing product or a placebo. Additionally, 120 subjects with facial tanning were given either a 2%
Niacinamide cream containing a sunscreen, a sunscreen, or a vehicle. Changes in facial pigmentation were evaluated via computer analysis and visual grading of high-resolution digital images of the face. Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared to vehicle alone after four weeks of use. Other studies have been reported whereby topical Niacinamide application demonstrates improvement of barrier function via decreased transepidermal water loss (TEWL) and skin appeared to be more resistant to irritation produced by topical irritants such as detergents (19,20).
2. Key benefits: Decreases hyperpigmentation and may improve barrier function and resiliency to environmental insults.
3. Primary adverse effects: Well tolerated.
4. Practical applications in dermatology: Niacinamide may be a suitable replacement for treating hyperpigmentation when results are not obtainable with hydroquinone and/or other conventional forms of treatment.