Escin

Derived from horse chestnut (Aesculus hippocastanum), this ingredient has been pre­scribed as an oral supplement to reduce some symptoms of chronic vein insufficiency, such as varicose veins, pain, tiredness, tension, swelling in the legs, itching, and edema. However, because horse chestnut contains significant amounts of the toxin esculin, it can be lethal, and other experts recommend not using it. When applied topically, however, there is research showing that a gel containing 2% escin can improve circulation. Results from another study showed a reduction in inflammation in sports injuries when escin was combined with heparin (a mucopolysaccharide used as an anti-clotting medication), and a form of salicylic acid (diethylammonium salicylate). Escin is also a potent antioxidant. As a skin-care ingredient escin clearly has a place, but as for improving cellulite that’s another story. While it may seem logical that blood flow and cellulite are related, the research just isn’t there to support the notion, or your thighs. Plus, cellulite products contain far less of this ingredient than the amount used in the studies. (Sources: British Journal of Sports Medicine, 36 June 2002, pages 183-188; Angiology, March 2000, pages 197-205; www. naturaldatabase. com; International Journal of Cosmetic Science, December 1999, page 437; and Archives of Dermatology, November 1998, pages 1356-1360.)