Azelaic acid

Azelaic acid is typically prescribed for rosacea and some acne conditions. Recently, the potential for using azelaic acid to treat androgenetic alopecia has been discussed. Accord­ing to Kevin J. McElwee, an immunologist/dermatologist involved in research on hair loss and regrowth, “Studies carried out in France in the late 80’s were to assess the effects of zinc sulfate and azelaic acid on the human skin. The result of these studies demonstrated that at high concentrations, zinc could completely inhibit the activity of 5-alpha reductase. Azelaic acid was also shown to be a potent inhibitor of 5-alpha reductase. Inhibition was detectable at concentrations as low as 0.2mmol/l and was complete at 3mmol/l. When zinc, vitamin B6, and azelaic acid were added together at very low concentrations, which had been ineffective alone, 90% inhibition of 5-alpha reductase was achieved” (Source: Brit­ish Journal of Dermatology, November 1988, pages 627-632). However, there is no other research showing azelaic acid to be useful for hair regrowth. Even the Web sites that claim there are numerous studies list no other sources.